| dc.identifier.uri | http://hdl.handle.net/1951/59629 | |
| dc.identifier.uri | http://hdl.handle.net/11401/71202 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dc.type | Thesis | |
| dcterms.abstract | The total synthesis of immunosuppressant and multidrug resistant (MDR) reversal agents SNF4435 C and SNF4435 D, isolated from the culture broth of an Okinawan strain of Streptomyces spectabilis in 2001, has been accomplished in a fourteen step process. The key reaction utilizes a Stille coupling en route to the final products. Considering the limitations of the Stille coupling, we are currently adjusting the procedure to allow for a new approach, which involves the use of a molecular tether to join the two precursor molecules. This thesis describes the synthesis of a new pair of precursors as well as our efforts toward linking said molecules together via an appropriate silicon bridge. | |
| dcterms.available | 2013-05-22T17:34:24Z | |
| dcterms.available | 2015-04-24T14:46:29Z | |
| dcterms.contributor | Drueckhammer, Dale | en_US |
| dcterms.contributor | Parker, Kathlyn A | en_US |
| dcterms.contributor | Johnson, Francis. | en_US |
| dcterms.creator | Dick, Andrew Daniel | |
| dcterms.dateAccepted | 2013-05-22T17:34:24Z | |
| dcterms.dateAccepted | 2015-04-24T14:46:29Z | |
| dcterms.dateSubmitted | 2013-05-22T17:34:24Z | |
| dcterms.dateSubmitted | 2015-04-24T14:46:29Z | |
| dcterms.description | Department of Chemistry | en_US |
| dcterms.extent | 40 pg. | en_US |
| dcterms.format | Monograph | |
| dcterms.format | Application/PDF | en_US |
| dcterms.identifier | Dick_grad.sunysb_0771M_11232 | en_US |
| dcterms.identifier | http://hdl.handle.net/1951/59629 | |
| dcterms.identifier | http://hdl.handle.net/11401/71202 | |
| dcterms.issued | 2012-12-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Made available in DSpace on 2013-05-22T17:34:24Z (GMT). No. of bitstreams: 1
Dick_grad.sunysb_0771M_11232.pdf: 774755 bytes, checksum: 64615b9be30f9636311a8db94317b93f (MD5)
Previous issue date: 1 | en |
| dcterms.provenance | Made available in DSpace on 2015-04-24T14:46:29Z (GMT). No. of bitstreams: 3
Dick_grad.sunysb_0771M_11232.pdf.jpg: 1894 bytes, checksum: a6009c46e6ec8251b348085684cba80d (MD5)
Dick_grad.sunysb_0771M_11232.pdf.txt: 34623 bytes, checksum: 1bdafdd013f0ece954fd3d07d5d8805d (MD5)
Dick_grad.sunysb_0771M_11232.pdf: 774755 bytes, checksum: 64615b9be30f9636311a8db94317b93f (MD5)
Previous issue date: 1 | en |
| dcterms.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dcterms.subject | Organic chemistry | |
| dcterms.title | A New Approach to the Synthesis of the Bicyclic Core of the Immunosuppressants SNF4435 C & SNF4435 D via Silicon Tethering | |
| dcterms.type | Thesis | |
