| dc.identifier.uri | http://hdl.handle.net/1951/59774 | |
| dc.identifier.uri | http://hdl.handle.net/11401/71331 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dc.type | Thesis | |
| dcterms.abstract | Osteoporosis, a bone disease caused by the decreased mass and impaired structure of bone, is becoming an increasing threat to the health of the elderly population. To treat and prevent this kind of suffering, understanding of the bone formation and regeneration is of significant importance, during which bone cell-biomaterial interaction plays a critical role, especially osteoblasts. In this work, we report an in situ investigation of osteoblast proliferation, migration and differentiation on a series of substrates with variable surface chemistry as a result of coating fabrication. Primary investigation indicated that cells migrated faster on sulfonated polystyrene (SPS)-coated MirrIR slides than uncoated slides but grew slower. Cell elongation results were well consistent with the migration data. To explain these differences, hydrophilicity of SPS-coated and uncoated slides was measured, which turned out that SPS coating made the slides more hydrophobic. However, to successfully explain the results one challenge is that multiple discrepancies co-exist between SPS-coated and uncoated MirrIR slides, excluding surface chemistry, surface roughness and surface charge, which requires future work focusing on realization of univariate parameter at one time. Final understanding of effects of individual parameter listed above on osteoblast proliferation, migration and differentiation is hopeful to help design new implantable materials for clinical surgery. | |
| dcterms.available | 2013-05-22T17:35:10Z | |
| dcterms.available | 2015-04-24T14:47:04Z | |
| dcterms.contributor | Gersappe, Dilip | en_US |
| dcterms.contributor | Meng, Yizhi | en_US |
| dcterms.contributor | Qin, Yi-Xian. | en_US |
| dcterms.creator | Lu, Xia | |
| dcterms.dateAccepted | 2013-05-22T17:35:10Z | |
| dcterms.dateAccepted | 2015-04-24T14:47:04Z | |
| dcterms.dateSubmitted | 2013-05-22T17:35:10Z | |
| dcterms.dateSubmitted | 2015-04-24T14:47:04Z | |
| dcterms.description | Department of Materials Science and Engineering | en_US |
| dcterms.extent | 59 pg. | en_US |
| dcterms.format | Application/PDF | en_US |
| dcterms.format | Monograph | |
| dcterms.identifier | Lu_grad.sunysb_0771M_10829 | en_US |
| dcterms.identifier | http://hdl.handle.net/1951/59774 | |
| dcterms.identifier | http://hdl.handle.net/11401/71331 | |
| dcterms.issued | 2011-12-01 | |
| dcterms.language | en_US | |
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Previous issue date: 1 | en |
| dcterms.provenance | Made available in DSpace on 2015-04-24T14:47:04Z (GMT). No. of bitstreams: 3
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Previous issue date: 1 | en |
| dcterms.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dcterms.subject | Materials Science | |
| dcterms.title | Investigation of Materials Surface Chemistry on Osteoblast Proliferation, Migration and Differentiation | |
| dcterms.type | Thesis | |
