| dc.identifier.uri | http://hdl.handle.net/11401/76903 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dc.type | Thesis | |
| dcterms.abstract | Notch signaling plays an essential role in metazoan development, and dysregulation of its activity has been recognized as a cause for many diseases. The extracellular domain of the Notch receptor has numerous tandem epidermal growth factor-like repeats modified with O-fucose and O-glucose glycans that play important roles in Notch function. Elongation of O-fucose by β 3-N-acetylglucosaminyltransferases of the Fringe family is known to modulate Notch activity. In addition, preliminary data from the Haltiwanger laboratory suggests that one of the Fringe enzymes, Lunatic Fringe, may modify itself. Lunatic Fringe does not contain any epidermal growth factor-like repeats and is not known to be modified by O-fucose, but it is modified with an N-linked glycan that may contain fucose. Our hypothesis is that Lunatic Fringe may modify itself on a fucose linked to an N-glycan. The goal of this project is to characterize the structure of the N-linked glycans attached to Lunatic Fringe and to further examine the self-modification of Lunatic Fringe. | |
| dcterms.available | 2017-09-20T16:51:25Z | |
| dcterms.contributor | Haltiwanger, Robert S | en_US |
| dcterms.contributor | Lyman, Harvard. | en_US |
| dcterms.creator | Aslam, Usman | |
| dcterms.dateAccepted | 2017-09-20T16:51:25Z | |
| dcterms.dateSubmitted | 2017-09-20T16:51:25Z | |
| dcterms.description | Department of Biochemistry and Cell Biology. | en_US |
| dcterms.extent | 57 pg. | en_US |
| dcterms.format | Monograph | |
| dcterms.format | Application/PDF | en_US |
| dcterms.identifier | http://hdl.handle.net/11401/76903 | |
| dcterms.issued | 2013-12-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Made available in DSpace on 2017-09-20T16:51:25Z (GMT). No. of bitstreams: 1
Aslam_grad.sunysb_0771M_11617.pdf: 4069245 bytes, checksum: 482edf31cfa2d9bc716bc13176617d08 (MD5)
Previous issue date: 1 | en |
| dcterms.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dcterms.subject | Biochemistry | |
| dcterms.title | Does Lunatic Fringe Modify Itself? | |
| dcterms.type | Thesis | |
