Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer’s Disease
Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer’s Disease
| dc.identifier.uri | http://hdl.handle.net/11401/77007 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dc.type | Dissertation | |
| dcterms.abstract | Despite numerous advances in our understanding of the mechanisms that underlie Alzheimer’s disease (AD), there is still no cure, and the disease continues to pose a severe public health problem. It has become clear that many factors, including certain lifestyle practices, may contribute to the development of the disease; however, much remains to be learned about how lifestyle factors may prevent or delay cognitive decline. Unlike human epidemiological studies, murine models can provide clearer inferences about causality. The present studies focus on two lifestyle factors: cognitive enrichment and cardio-vascular exercise. Specifically, the effects of lifestyle interventions on behavioral performance and pathology were studied in a transgenic murine model of vascular amyloid pathology, the Tg-SwDI. The vascular component of this model’s pathology is an important feature of AD pathology that shows particular promise for being responsive to these interventions. The first two studies examined the effects of a novel, progressive cognitive training intervention on pathology and behavior in three-month-old Tg-SwDI mice, as well as in a model of parenchymal amyloid (Tg-5xFAD mice). Only marginal improvements were observed in cognitive measures, without corresponding changes in gross or regional levels of amyloid pathology or in levels of regional neuroinflammation. These data do not support the value of isolated cognitive training regimens, though the feasibility of this approach in murine models is demonstrated. The final study examined the impact of four months of 1, 3, or 12-hours of voluntary cardiovascular exercise on cognitive-behavioral measures in three-month-old Tg-SwDI and healthy wild-type mice. Exercise effects were evident across multiple behavioral measures, but did not provide reliable improvement of performance across tests. Taken together, these results highlight the potential for differential susceptibility of particular features of AD to the effects of lifestyle. | |
| dcterms.abstract | Despite numerous advances in our understanding of the mechanisms that underlie Alzheimer’s disease (AD), there is still no cure, and the disease continues to pose a severe public health problem. It has become clear that many factors, including certain lifestyle practices, may contribute to the development of the disease; however, much remains to be learned about how lifestyle factors may prevent or delay cognitive decline. Unlike human epidemiological studies, murine models can provide clearer inferences about causality. The present studies focus on two lifestyle factors: cognitive enrichment and cardio-vascular exercise. Specifically, the effects of lifestyle interventions on behavioral performance and pathology were studied in a transgenic murine model of vascular amyloid pathology, the Tg-SwDI. The vascular component of this model’s pathology is an important feature of AD pathology that shows particular promise for being responsive to these interventions. The first two studies examined the effects of a novel, progressive cognitive training intervention on pathology and behavior in three-month-old Tg-SwDI mice, as well as in a model of parenchymal amyloid (Tg-5xFAD mice). Only marginal improvements were observed in cognitive measures, without corresponding changes in gross or regional levels of amyloid pathology or in levels of regional neuroinflammation. These data do not support the value of isolated cognitive training regimens, though the feasibility of this approach in murine models is demonstrated. The final study examined the impact of four months of 1, 3, or 12-hours of voluntary cardiovascular exercise on cognitive-behavioral measures in three-month-old Tg-SwDI and healthy wild-type mice. Exercise effects were evident across multiple behavioral measures, but did not provide reliable improvement of performance across tests. Taken together, these results highlight the potential for differential susceptibility of particular features of AD to the effects of lifestyle. | |
| dcterms.available | 2017-09-20T16:51:38Z | |
| dcterms.contributor | Robinson, John K | en_US |
| dcterms.contributor | Anderson, Brenda | en_US |
| dcterms.contributor | Gerrig, Richard | en_US |
| dcterms.contributor | VanNostrand, William. | en_US |
| dcterms.creator | Anderson, Maria Elizabeth | |
| dcterms.dateAccepted | 2017-09-20T16:51:38Z | |
| dcterms.dateSubmitted | 2017-09-20T16:51:38Z | |
| dcterms.description | Department of Biopsychology. | en_US |
| dcterms.extent | 163 pg. | en_US |
| dcterms.format | Application/PDF | en_US |
| dcterms.format | Monograph | |
| dcterms.identifier | http://hdl.handle.net/11401/77007 | |
| dcterms.issued | 2015-12-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Made available in DSpace on 2017-09-20T16:51:38Z (GMT). No. of bitstreams: 1 Anderson_grad.sunysb_0771E_12419.pdf: 20441460 bytes, checksum: 63d5fc2847093842563e94e902388b06 (MD5) Previous issue date: 1 | en |
| dcterms.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dcterms.subject | Alzheimer's disease, Cardiovascular exercise, Cognitive enrichment, Transgenic murine models | |
| dcterms.subject | Neurosciences | |
| dcterms.title | Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer’s Disease | |
| dcterms.title | Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer’s Disease | |
| dcterms.type | Dissertation |
