| dc.identifier.uri | http://hdl.handle.net/11401/77113 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dc.type | Thesis | |
| dcterms.abstract | Amphiphilic block copolymers have attracted much research interest due to their potential applications in various areas, such as drug delivery and gene therapy and. Those polymers usually contain hydrophobic and hydrophilic blocks, which allow them to undergo self-assemby in aqueous solution. Thermally-responsive amphiphilic copolymers have been investigated by our group. Thermally-responsive blocks which have a lower critical solution temperature (LCST) will become insoluble in aqueous solution upon heating and induce the morphological changes in copolymer assembly. In this project, amphiphilic tri-arm star copolymer which contains one hydrophilic polyethylene glycol (PEG) block, one hydrophobic polylactide (PLA) block and one thermally-responsive Poly(N,N-diethylacrylamide) (PDEAm) block with a LCST at 30 °C have been synthesized. A mPEG-S(BOC)-OH macroinitiator was used to initiate ring-opening polymerization of lactide to afford diblock mPEG-S(BOC)-PLA. After successful removal of BOC protecting group, N-acryloxysuccinimide (NASI) was used as the linking agent to connect the diblock PEG-S(NH2)-PLA with a thiol-terminated PDEAm block prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The thermally-responsive behavior of the copolymer will be studied with dynamic light scattering (DLS). | |
| dcterms.abstract | Amphiphilic block copolymers have attracted much research interest due to their potential applications in various areas, such as drug delivery and gene therapy and. Those polymers usually contain hydrophobic and hydrophilic blocks, which allow them to undergo self-assemby in aqueous solution. Thermally-responsive amphiphilic copolymers have been investigated by our group. Thermally-responsive blocks which have a lower critical solution temperature (LCST) will become insoluble in aqueous solution upon heating and induce the morphological changes in copolymer assembly. In this project, amphiphilic tri-arm star copolymer which contains one hydrophilic polyethylene glycol (PEG) block, one hydrophobic polylactide (PLA) block and one thermally-responsive Poly(N,N-diethylacrylamide) (PDEAm) block with a LCST at 30 °C have been synthesized. A mPEG-S(BOC)-OH macroinitiator was used to initiate ring-opening polymerization of lactide to afford diblock mPEG-S(BOC)-PLA. After successful removal of BOC protecting group, N-acryloxysuccinimide (NASI) was used as the linking agent to connect the diblock PEG-S(NH2)-PLA with a thiol-terminated PDEAm block prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The thermally-responsive behavior of the copolymer will be studied with dynamic light scattering (DLS). | |
| dcterms.available | 2017-09-20T16:51:59Z | |
| dcterms.contributor | Grubbs, Robert B | en_US |
| dcterms.contributor | Bhatia, Surita | en_US |
| dcterms.contributor | Ojima, Iwao. | en_US |
| dcterms.creator | Jiang, Menglan | |
| dcterms.dateAccepted | 2017-09-20T16:51:59Z | |
| dcterms.dateSubmitted | 2017-09-20T16:51:59Z | |
| dcterms.description | Department of Chemistry. | en_US |
| dcterms.extent | 41 pg. | en_US |
| dcterms.format | Application/PDF | en_US |
| dcterms.format | Monograph | |
| dcterms.identifier | http://hdl.handle.net/11401/77113 | |
| dcterms.issued | 2014-12-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Made available in DSpace on 2017-09-20T16:51:59Z (GMT). No. of bitstreams: 1
Jiang_grad.sunysb_0771M_11862.pdf: 1548971 bytes, checksum: b4eff9b1984477d8cde85e654b9ed5ee (MD5)
Previous issue date: 1 | en |
| dcterms.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dcterms.subject | amphiphilic copolymer, thermally-responsive polymer | |
| dcterms.subject | Chemistry | |
| dcterms.title | Synthesis of Thermally-responsive Amphiphilic Tri-Arm Star Copolymers | |
| dcterms.type | Thesis | |
