| dc.identifier.uri | http://hdl.handle.net/11401/77126 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dc.type | Thesis | |
| dcterms.abstract | Nucleic acid mimics and analogs are artificially designed molecular strands that can bind to natural nucleic acids. They have far-reaching diagnostics and therapeutics applications. An ideal nucleic acid mimic should exhibit strong binding affinity to complementary DNA or RNA and excellent resistance to nucleases. Numerous nucleic acid mimics such as PNA, LNA and morpholino oligonucleotides have been studied for decades. In our study, we aim to synthesize novel improved nucleic acid analogs. We have designed various nucleic acid mimics by computational methods. An analog was chosen for synthesis consisting of a piperidine backbone and a " sandwich" base that intercalates adjacent base pairs. This thesis describes the development of synthetic routes to the " sandwich" base and exploration of a route to the piperidine backbone. | |
| dcterms.available | 2017-09-20T16:52:02Z | |
| dcterms.contributor | Rudick, Jonathan | en_US |
| dcterms.contributor | Drueckhammer, Dale G. | en_US |
| dcterms.contributor | Parker, Kathlyn. | en_US |
| dcterms.creator | Liu, Xiao | |
| dcterms.dateAccepted | 2017-09-20T16:52:02Z | |
| dcterms.dateSubmitted | 2017-09-20T16:52:02Z | |
| dcterms.description | Department of Chemistry. | en_US |
| dcterms.extent | 63 pg. | en_US |
| dcterms.format | Monograph | |
| dcterms.format | Application/PDF | en_US |
| dcterms.identifier | http://hdl.handle.net/11401/77126 | |
| dcterms.issued | 2015-08-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Made available in DSpace on 2017-09-20T16:52:02Z (GMT). No. of bitstreams: 1
Liu_grad.sunysb_0771M_11484.pdf: 3833369 bytes, checksum: ecc3728a8d97ccf3f189c69054e83d70 (MD5)
Previous issue date: 2014 | en |
| dcterms.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dcterms.subject | Chemistry | |
| dcterms.title | Synthesis of a Novel Sandwich Base Nucleic Acid Analog | |
| dcterms.type | Thesis | |
