| dc.identifier.uri | http://hdl.handle.net/11401/78278 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.type | Dissertation | |
| dcterms.abstract | Adult brains are constantly reshaping themselves from synapses to circuits as we encounter novel experiences from moment to moment. Importantly, this reshaping also includes the addition of newborn hippocampal neurons. However, it remains largely unknown how our circuits encode experience-induced brain activity to govern the addition of new hippocampal neurons. By coupling in vivo Ca2+ imaging of dentate granule neurons with a novel, unrestrained virtual reality system for rodents, we discovered that a new experience rapidly and robustly increased the firing of active dentate granule neurons, and was accompanied by an accumulative enhancement in the addition of new hippocampal neurons. Silencing this activation optogenetically during novel experiences perturbed experience-induced neuronal addition. Given the high metabolic demands associated with maintaining a continuous pool of proliferating and maturing cells, we next asked whether the addition of new hippocampal neurons is regulated by the vascular supply. We developed a technique to non-invasively target astrocytes, cells that couple neuronal activity to vascular recruitment. Upon genetic ablation of astrocytes, we observed sharply decreased survival of newborn hippocampal neurons. Together, these data provide new insights into how experience and brain activity shape the ongoing generation of new neurons in the adult brain. | |
| dcterms.available | 2018-06-21T13:38:52Z | |
| dcterms.contributor | Ge, Shaoyu | en_US |
| dcterms.contributor | Parsey, Ramin | en_US |
| dcterms.contributor | Enikolopov, Grigori | en_US |
| dcterms.contributor | Role, Lorna | en_US |
| dcterms.contributor | Hen, René | en_US |
| dcterms.creator | Kirschen, Gregory Wohl | |
| dcterms.dateAccepted | 2018-06-21T13:38:52Z | |
| dcterms.dateSubmitted | 2018-06-21T13:38:52Z | |
| dcterms.description | Department of Molecular and Cellular Pharmacology | en_US |
| dcterms.extent | 169 pg. | en_US |
| dcterms.format | Application/PDF | en_US |
| dcterms.format | Monograph | |
| dcterms.identifier | http://hdl.handle.net/11401/78278 | |
| dcterms.issued | 2017-12-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Made available in DSpace on 2018-06-21T13:38:52Z (GMT). No. of bitstreams: 1
Kirschen_grad.sunysb_0771E_13556.pdf: 6715003 bytes, checksum: 5cd4d079331d5501eb097f2d3f5c9dc1 (MD5)
Previous issue date: 12 | en |
| dcterms.subject | Neurosciences | |
| dcterms.subject | adult neurogenesis | |
| dcterms.subject | enriched environment | |
| dcterms.subject | Pharmacology | |
| dcterms.subject | hippocampus | |
| dcterms.subject | neural stem cells | |
| dcterms.title | Brain activity instructs new hippocampal neuron addition: Insights from virtual reality | |
| dcterms.type | Dissertation | |
