| dc.identifier.uri | http://hdl.handle.net/11401/78298 | |
| dc.format | application/pdf | |
| dcterms.abstract | AMPARs play an essential role in fast excitatory neurotransmission. Before native AMPARs can function at the synapse they must be processed intracellularly. These ion channels are synthesized and assembled into multimeric complexes, shuttled in a regulated fashion between intracellular compartments and are finally inserted into the membrane to carry out their function. Important binding partners known as auxiliary subunits associate with AMPARs at the synapse, but also during assembly and trafficking. The presence of auxiliary subunits in AMPAR complexes at the membrane has been demonstrated through electrophysiological studies, showing effects on the gating and pharmacology of AMPARs. The localization of AMPAR-auxiliary subunits complexes in cellular compartments has not been well characterized, and the stoichiometry of these auxiliary subunits for appropriate function is not known. The main objective is to further characterize auxiliary subunits beyond their effects on AMPAR gating at the synapse. Cerebellar Granule Neurons were to be used as the native environment to study AMPAR-auxiliary complexes to address both the localization of these complexes and the stoichiometry of auxiliary subunits. The prediction is that auxiliary subunits complex with AMPARs in a compartment-specific manner and this allows for the appropriate processing of AMPARs. | |
| dcterms.available | 2020-02-13 | |
| dcterms.contributor | Advisors: Wollmuth, Lonnie P; Hsieh, Helen | en_US |
| dcterms.creator | Certain, Noele Doreen | |
| dcterms.date | 2017 | |
| dcterms.dateAccepted | 2018-07-03T17:18:31Z | |
| dcterms.dateSubmitted | 2018-07-03T17:18:31Z | |
| dcterms.description | Department of Biochemistry and Cell Biology | en_US |
| dcterms.description | Thesis | |
| dcterms.extent | 35 pages | en_US |
| dcterms.identifier | http://hdl.handle.net/11401/78298 | |
| dcterms.identifier | Certain_grad.sunysb_0771M_13604.pdf | |
| dcterms.issued | 2017-12-01 | |
| dcterms.language | en | |
| dcterms.provenance | Submitted by Jason Torre (fjason.torre@stonybrook.edu) on 2018-07-03T17:18:31Z
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Certain_grad.sunysb_0771M_13604.pdf: 886812 bytes, checksum: 7ac26f85d201193f651f7b4b7ee64b5e (MD5) | en |
| dcterms.provenance | Made available in DSpace on 2018-07-03T17:18:31Z (GMT). No. of bitstreams: 1
Certain_grad.sunysb_0771M_13604.pdf: 886812 bytes, checksum: 7ac26f85d201193f651f7b4b7ee64b5e (MD5)
Previous issue date: 2017-12-01 | en |
| dcterms.publisher | Stony Brook University | |
| dcterms.subject | Neurosciences, Biochemistry, Cytology | |
| dcterms.title | The Intracellular Cell Biology of Ionotropic Glutamate Receptors | |
| dcterms.type | Text | |
