| dc.identifier.uri | http://hdl.handle.net/11401/78318 | |
| dcterms.abstract | Optical domain technologies can provide high spatiotemporal resolution for biomedical research and therefore attract tremendous interests in multiple disciplines including psychiatry, neurology, ophthalmology, oncology, urology and many more. Optical coherence tomography (OCT), after more than 20 years of development, has been becoming one of the most widely-used bio-optical modalities not only for laboratory-based research but also for clinical applications. For example, OCT becomes the standard of care for diagnosing glaucoma. Additionally, its derived velocimetry, optical coherence Doppler tomography (ODT), also demonstrates the unique capability of mapping cerebral blood flow velocity (CBFv) of vascular networks with capillary resolution (&phis;<6µm) and thus allows for the widespread utilization in numerous neurology studies. Although ODT has been widely used in biomedical research, there remain several technical limitations including the shallow penetration depth, low sensitivity for imaging slow flow in capillary and the measurement error due to Doppler angle. To address these challenges, viable solutions are proposed in this dissertation. Chapter 1 starts with a comprehensive review over basic principle of OCT and ODT. Chapter 2-4 explicitly address these OCT technical challenges, for instance, using a 1310nm super-luminescent Diode (SLD) laser source to extend optical penetration depth, utilizing optical contrast agent: intralipid to enhance ODT’s sensitivity for capillary flow detection, implementing numerical methods to extend ODT’s dynamic range and decouple Doppler angle. In addition to these technical improvements, Chapter 5-6 address two biomedical challenges in oncology and psychiatry. Specifically, Chapter 5 introduces a longitudinal optical access to rodent cerebral vasculature and a method of tumor boundary detection, which provides a powerful insight into the tumor progression. Chapter 6 reveals the close correlation between cocaine-elicited transient ischemic attack (TIA) and hypo-perfused cortex. Chapter 7 focuses on the development of multi-modality system and novel imaging scheme for the study of neurovascular coupling. Chapter 8 briefly concludes the contents presented in this dissertation and outlines the future development and potential applications of ODT. | |
| dcterms.available | 2018-08-13 | |
| dcterms.contributor | Advisors: Pan, Yingtian; Jia, Shu; Du, Congwu; Tsirka, Styliani-Anna (Stella) E. | |
| dcterms.creator | You, Jiang | |
| dcterms.date | 2017 | |
| dcterms.dateAccepted | 2018-07-03T17:51:18Z | |
| dcterms.dateSubmitted | 2018-07-03T17:51:18Z | |
| dcterms.description | Department of Biomedical Engineering | |
| dcterms.description | Dissertation | |
| dcterms.extent | 129 pages | |
| dcterms.format | application/pdf | |
| dcterms.identifier | You_grad.sunysb_0771E_13561.pdf | |
| dcterms.identifier | http://hdl.handle.net/11401/78318 | |
| dcterms.issued | 2017-12-01 | |
| dcterms.language | en | |
| dcterms.provenance | Submitted by Jason Torre (fjason.torre@stonybrook.edu) on 2018-07-03T17:51:18Z
No. of bitstreams: 1
You_grad.sunysb_0771E_13561.pdf: 10534591 bytes, checksum: de66242e1314bf403e4e9792567e30c3 (MD5) | |
| dcterms.provenance | Made available in DSpace on 2018-07-03T17:51:18Z (GMT). No. of bitstreams: 1
You_grad.sunysb_0771E_13561.pdf: 10534591 bytes, checksum: de66242e1314bf403e4e9792567e30c3 (MD5)
Previous issue date: 2017-12-01 | |
| dcterms.publisher | Stony Brook University | |
| dcterms.subject | Biomedical engineering, Cocaine, Neurosciences, Microvascular dynamics, Optics, Optical coherence tomography, vasoconstriction | |
| dcterms.title | Quantitative imaging of 3D cerebral microvascular network dynamics by ultrahigh -resolution optical coherence Doppler tomography (μODT) | |
| dcterms.type | Text | |
