| dc.identifier.uri | http://hdl.handle.net/11401/78349 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.format.mimetype | Application/PDF | en_US |
| dc.language.iso | en_US | |
| dc.type | Thesis | |
| dcterms.abstract | Despite recent advances in the detection and treatment of cancer, it remains the second most common cause of death in the United States, second only to heart disease. It is estimated that half of all men and a third of all women in America will develop cancer in their lifetimes. Traditional chemotherapy is predicated on the idea that rapidly dividing cells (such as tumor cells in nascent stages of cancer development), can be targeted preferentially by chemotherapeutic agents. Commonly, plant alkaloids, such as vincristine and paclitaxel, have been utilized to induce apoptosis in cancer cells. Next generation taxoid SB-T-1214, a taxoid superior to paclitaxel, was synthesized. Molecular dynamics simulations of the further improved third generation taxoids SB-T-1214-05 and SB-T-1214-06 were performed to investigate the discrepancy in their potencies against certain cancer cell lines. Another natural product, Combretastatin A-4 (CA4) is known to act as a vascular disrupting agent (VDA) by increasing the permeability of tumor vasculature, causing leakage of plasma proteins and reduction of vessel diameter. The reduction in diameter causes high interstitial fluid pressure and results in red blood cell stacking, increasing the viscosity of the blood and effectively choking the tumor of nutrients, resulting in tumor necrosis. In this research, novel fluorine-containing CA4 analogs were designed following virtual screening using DOCK 6.7 and use of docking software with Glide and Autodock Vina. The analogs were synthesized for evaluation against different cancer cell lines. | |
| dcterms.available | 2018-07-09T13:54:32Z | |
| dcterms.contributor | Drueckhammer, Dale G. | en_US |
| dcterms.contributor | Ojima, Iwao. | en_US |
| dcterms.contributor | Goroff, Dancy S. | en_US |
| dcterms.creator | Maffucci, Katherine | |
| dcterms.dateAccepted | 2018-07-09T13:54:32Z | |
| dcterms.dateSubmitted | 2018-07-09T13:54:32Z | |
| dcterms.description | Department of Chemistry. | en_US |
| dcterms.extent | 121 pg. | en_US |
| dcterms.format | Monograph | |
| dcterms.identifier | http://hdl.handle.net/11401/78349 | |
| dcterms.identifier | Maffucci_grad.sunysb_0771M_13464.pdf | en_US |
| dcterms.issued | 2017-08-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Submitted by Jason Torre (fjason.torre@stonybrook.edu) on 2018-07-09T13:54:32Z
No. of bitstreams: 1
Maffucci_grad.sunysb_0771M_13464.pdf: 5586014 bytes, checksum: ddd1c805684fc31d319c36694f3138c6 (MD5) | en |
| dcterms.provenance | Made available in DSpace on 2018-07-09T13:54:32Z (GMT). No. of bitstreams: 1
Maffucci_grad.sunysb_0771M_13464.pdf: 5586014 bytes, checksum: ddd1c805684fc31d319c36694f3138c6 (MD5)
Previous issue date: 2017-08-01 | en |
| dcterms.subject | Chemistry, Organic | |
| dcterms.subject | Cytology | |
| dcterms.title | Computational Design and Synthesis of Novel Fluorine-Containing Combretastatin A-4 Analogs and Synthesis of SB-T-1214 | |
| dcterms.type | Thesis | |
